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I am not sure why you would need to render someone unconscious unless they were attacking you or something like that. If you are trying to protect yourself, hitting them in the head
http://answers.ask.com/Health/Diseases/how_to_rend...
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You can knock someone unconscious many different ways but this is not a good thing to even try to do. You can cause someone permanent serious injury or even death.
http://answers.ask.com/Health/Diseases/how_to_knoc...
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There are games that teens and pre-teens play that help make you unconscious very quickly, but they are dangerous and have even resulted in death.
http://answers.ask.com/Health/Other/how_to_make_so...
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To make someone unconscious without using drugs you could simply deck them. There is a nerve in the chin, when hit in an upward fashion is causes the other person to go unconscious.
http://answers.ask.com/Health/Diseases/how_to_make...
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